sodium [2s-[2alpha,5alpha,6beta(s*)]]-6-(aminophenylacetamido)-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate
Ampicillin Na
CAS: 69-52-3
Molecular Formula: C16H18N3NaO4S
sodium [2s-[2alpha,5alpha,6beta(s*)]]-6-(aminophenylacetamido)-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate - Names and Identifiers
sodium [2s-[2alpha,5alpha,6beta(s*)]]-6-(aminophenylacetamido)-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate - Physico-chemical Properties
| Molecular Formula | C16H18N3NaO4S |
| Molar Mass | 371.39 |
| Melting Point | 215°C (dec.)(lit.) |
| Specific Rotation(α) | +246～+272° |
| Water Solubility | Freely soluble in water. Sparingly soluble in acetone |
| Solubility | Soluble in water. |
| Appearance | powder |
| Color | white with slight yellow cast |
| BRN | 4119211 |
| PH | pH(100g/l, 25℃):8.0～10.0 |
| Storage Condition | 2-8°C |
| MDL | MFCD00064313 |
| Physical and Chemical Properties | Melting Point: 215°C |
| Use | Is a semi-synthetic broad-spectrum penicillin, mainly used for penicillin-sensitive Gram-positive cocci, Escherichia coli, Proteus, Salmonella, Shigella and other treatment |
sodium [2s-[2alpha,5alpha,6beta(s*)]]-6-(aminophenylacetamido)-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate - Risk and Safety
| Risk Codes | R42/43 - May cause sensitization by inhalation and skin contact. R36/37/38 - Irritating to eyes, respiratory system and skin. R22 - Harmful if swallowed |
| Safety Description | S22 - Do not breathe dust. S36/37 - Wear suitable protective clothing and gloves. S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) S36 - Wear suitable protective clothing. S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. |
| WGK Germany | 2 |
| RTECS | XH8400000 |
| FLUKA BRAND F CODES | 3-10 |
| HS Code | 29419000 |
| Toxicity | LD50 oral in rat: > 5314mg/kg |
sodium [2s-[2alpha,5alpha,6beta(s*)]]-6-(aminophenylacetamido)-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate - Upstream Downstream Industry
sodium [2s-[2alpha,5alpha,6beta(s*)]]-6-(aminophenylacetamido)-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate - Reference
| Reference Show more | 1. Zhang Bo, Fan Chao, Hong Hao, etc. Whole-cell catalytic synthesis of β-alanine by recombinant Escherichia coli [J]. Journal of Dalian Polytechnic University, 2020(2):108-112. 2. Gao Ming-kun, Zhang Zhi, Qian Fang. Toxicity and functional test of mixed bacterial preparation (BMX) and its effect on fattening pigs [J]. Feed Research, 2018, No.485(04):66-71. 3. Xue Mengying, Li Lu, Zhang Huafeng, Liu Ziqi. Seasonal variation of flavonoids, alkaloids and antimicrobial activities of three species of Ceratopogonidae [J]. Grassland Science 2018 35(11):2614-2621. 4. Wu Qin, Xu Ziyang, Liu Liping, etc. Role of gut microbiota in stress-induced hypertension in rats [J]. Biotechnology Bulletin, 2020, v.36;No.331(02):88-95. 5. Dong Bilian, Cai yanqu, Zhu Zhidong, Zhu Shengshan, Zhu Yujia. In vitro and in vivo antibacterial activity of Chinese herbal compound DC against standard Escherichia coli and ESBLs-producing Escherichia coli [J]. Journal of Guangdong Pharmaceutical University, 2020,36(06):809-814. 6. Nianyuan, Deng Yuanyuan, Wei Zhencheng, Zhang Yan, Tang Xiaojun, Li Ping, Zhou Pengfei, Liu Guang, Zhang famous. Expression and enzymatic characteristics of recombinant wheat resting thiol oxidase and its effect on bread quality [J]. Chinese Journal of bioengineering, 2021,37(02):593-603. 7. Zhang Zheng, Ma gengqin, Wang Hongxuan, Hou Wenfu, Zhou Min. Biological characteristics and multi-drug efflux pump expression of drug-resistant Vibrio parahaemolyticus [J]. Modern food science and technology, 2020,36(08):15-22. 8. Zheng Min, Xu Yifan, Chen Yanyan, Zhou Yijing, Zhang Yuheng, Yu xairui, Hong Min. Ganmai dazao decoction combined with fluoxetine improves depressive symptoms in mice with chronic stress by regulating intestinal flora [J]. Journal of Nanjing University of Traditional Chinese Medicine, 2020,36(05):667-674. 9. Zhang, Nan, et al. "alleviates antibiotic-associated diarrhea, modifies intestinal microbiota, and increases the level of short-chain fatty acids in mice." Food Research International 122 (2019): 191-198.https://doi. 10. Zhang, Fangxing, et al. "The Endogenous Alterations of the Gut Microbiota and Feces Metabolites Alleviate Oxidative Damage in the Brain of LanCL1 Knockout Mice." Frontiers in microbiology 11 (2020): 2126.https://doi.org/10.3389/fmicb.2020.557342 11. Raji, P. , et al. "Antibacterial Activity of Alkaloids, Flavonoids, Saponins and Tannins Mediated Green Synthesised Silver Nanoparticles Against Pseudomonas aeruginosa and Bacillus subtilis." Journal of Cluster Science 30.5(2019).DOI: 10.1007/s10876-019-01 12. [IF=6.475] Nan Zhang et al."Chinese yam (Dioscorea opposita Thunb.) alleviates antibiotic-associated diarrhea, modifies intestinal microbiota and increases the level of short-chain fatty acids in mice."Food Res Int. 2019 Aug;122:191 13. [IF=2.847] Feng Wang et al."Design, Overproduction and Purification of the Chimeric Phage Lysin MLTphg Fighting against Staphylococcus aureus."Processes. 2020 Dec;8(12):1587 14. [IF=10.588] Aiyun Guo et al.Prochloraz alone or in combination with nano-CuO promotes the conjugative transfer of antibiotic resistance genes between Escherichia coli in pure water.J Hazard Mater. 2022 Feb;424:127761 |
sodium [2s-[2alpha,5alpha,6beta(s*)]]-6-(aminophenylacetamido)-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate - Standard
Authoritative Data Verified Data
This product is (2S, 5R,6R)-3, 3-dimethyl-6-[ (sui-2-amino-2-phenylacetylamino]-7-oxo-4-thia-1-azabicyclo [3.2.0] heptane-sodium salt of 2-formate. The content of ampicillin (calculated as C16H19N304S) shall not be less than 85.0% calculated as anhydrous.
Last Update：2024-01-02 23:10:35
sodium [2s-[2alpha,5alpha,6beta(s*)]]-6-(aminophenylacetamido)-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate - Trait
Authoritative Data Verified Data
- This product is white or off-white powder or crystalline powder; Odorless or slightly odorous; With hygroscopicity.
- This product is soluble in water, slightly soluble in ethanol, insoluble in ethanol.
specific rotation
take this product, precision weighing, with 0.4% potassium hydrogen phthalate solution dissolved and quantitatively diluted to make a solution containing about 0621 mg per 1 ml, according to the law (general), the specific rotation is from +258 ° to +287 °.
Last Update：2022-01-01 15:37:06
sodium [2s-[2alpha,5alpha,6beta(s*)]]-6-(aminophenylacetamido)-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate - Introduction
Semi-synthetic penicillin, resistant to Gram-positive and negative bacteria. It is a β-lactamase antibiotic, and the amino group chain is connected to the penicillin structure. It is a penicillin derivative that relies on the inactivation of transpeptidase (transpeptidases) at the inner level of the bacterial cell membrane to inhibit the synthesis of the bacterial cell wall.
Last Update：2022-10-16 17:27:57
sodium [2s-[2alpha,5alpha,6beta(s*)]]-6-(aminophenylacetamido)-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate - Differential diagnosis
Authoritative Data Verified Data
- take an appropriate amount of this product and ampicillin reference, and add phosphate buffer solution (take anhydrous disodium hydrogen phosphate 0.50g and potassium dihydrogen phosphate 0.301g, add water to dissolve into 1000ml,pH 7.0) each solution containing about 1 mg per 1 ml was prepared by dissolving and diluting, and as a test solution and a reference solution, the above two solutions were mixed in equal amounts as a mixed solution. According to the thin layer chromatography (General 0502) test, draw 2ul of each of the above three solutions, respectively point on the same silica gel G thin layer plate, with acetone-water-toluene-glacial acetic acid (65:10:10:2.5) as the developing solvent, it was developed, dried, sprayed with 0.3% ninhydrin ethanol color developing solution, and heated at 90°C until spots appeared. The main spot displayed by the mixed solution should be a single spot, and the position and color of the main spot displayed by the test solution should be the same as that of the reference solution or the mixed solution.
- in the chromatogram recorded under the content determination item, the retention time of the main peak of the test solution should be consistent with the retention time of the main peak of the reference solution.
- The infrared absorption spectrum of this product should be consistent with that of the control (Spectrum set 1283).
- This product shows the reaction of sodium salt identification (1) (General rule 0301).
- two items (1) and (2) above can be selected as one item.
Last Update：2022-01-01 15:37:06
sodium [2s-[2alpha,5alpha,6beta(s*)]]-6-(aminophenylacetamido)-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate - Exam
Authoritative Data Verified Data
alkalinity
take this product, add water to make a solution containing 0.lg per lml, place it at room temperature for 10 minutes, and then measure it according to law (General rule 0631). The pH value should be 8.0~10.0.
clarity and color of solution
take 5 parts of this product, each 0.6g, respectively, after adding water 5ml to dissolve, the solution should be clear and colorless; If it is turbid, compare with No. 1 turbidity standard solution (General rule 0902 first method), shall not be more concentrated; If the color is developed, it shall not be deeper in comparison with the yellow-green No. 5 standard colorimetric solution (General Principles 0901 first method).
Related substances
take an appropriate amount of this product and weigh it accurately, add mobile phase A to dissolve and quantitatively dilute to prepare A solution containing about 3mg per 1 ml as A test solution, if there are impurity peaks in the chromatogram of the test solution, the ampicillin dimer shall not exceed 4.5% as calculated by the external standard method, the amount of other single impurities shall not exceed 2.0%, and the total amount of other impurities shall not exceed 5.0%.
residual solvent
take about 0.3g of this product, precision weighing, set in the top empty bottle, precision add water 3ml to dissolve, seal, as a test solution; Respectively, precision weighing acetone, ethyl acetate, isopropyl alcohol, methylene chloride, methyl isobutyl ketone, toluene and n-butyl alcohol were Diluted quantitatively with water to prepare acetone 0.5mg, ethyl acetate 0.5mg, isopropyl alcohol 0.5mg, dichloromethane 0.2mg, A mixed solution of methyl isobutyl ketone 0.5mg, toluene 89, and n-butanol 0.5mg was precisely weighed 3ml, placed in a headspace bottle, sealed, and used as a reference solution. According to the test for determination of residual solvents (General rule 0861 second method), the capillary column with Nitro-terephthalic acid-modified polyethylene glycol (or similar polarity) as stationary liquid is used as the chromatographic column, and the initial temperature is 60 ℃, hold for 6 minutes, then raise the temperature to 150°C at a rate of 20°C per minute for 8 minutes; The inlet temperature is 150°C; The detector temperature is 250°C; The equilibrium temperature of the headspace bottle is 80°C, the equilibration time was 30 minutes. The reference solution was injected in the headspace, and the chromatogram was recorded. The peaks were obtained according to the order of acetone, ethyl acetate, isopropanol, dichloromethane, methyl isobutyl ketone, toluene and n-butanol. Then take the sample solution and the reference solution into the headspace, record the chromatogram, and calculate the peak area according to the external standard method, Dichloromethane residues should not exceed 0.2%, acetone, ethyl acetate, isopropanol, methyl isobutyl ketone, toluene and n-butanol residues should be in accordance with the provisions.
2-ethylhexanoic acid
take this product, determination according to law (General Principles 0873), not over 0.8%.
moisture
take this product, according to the determination of moisture (General 0832 first method 1), the water content shall not exceed 2.0%.
Heavy metals
take this product l.O g, inspection according to law (General Principles 0821 second law), containing heavy metals shall not exceed 20 parts per million.
visible foreign body
take 5 parts of this product, each 2g, plus particle inspection water dissolution, inspection according to law (General 0904), should comply with the provisions. (For sterile packaging) insoluble particles take 3 parts of this product, and make a solution containing 50mg per lml of water for particle inspection, and check according to law (General rule 0903). In each lg sample, no more than 6000 particles containing lOum or more, and no more than 600 particles containing 25um or more. (For aseptic dispensing)
bacterial endotoxin
take this product, check according to law (General 1143), each 1 mg of ampicillin (according to C16H19N304S) in the amount of endotoxin should be less than 0.10EU. (For injection)
sterile
take this product, dissolve and dilute with appropriate solvent, after membrane filtration treatment, inspection according to law (General rule 1101), should comply with the provisions. (For aseptic dispensing)
Last Update：2022-01-01 15:37:07
sodium [2s-[2alpha,5alpha,6beta(s*)]]-6-(aminophenylacetamido)-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate - Content determination
Authoritative Data Verified Data
take an appropriate amount of this product, precision weighing, and add the mobile phase A under the item of related substances to dissolve and quantitatively dilute to prepare A solution containing about 1mg of ampicillin (based on C16H19N304S) per 1 ml, as a test solution, ampicillin was measured according to the method described above.
Last Update：2022-01-01 15:37:08
sodium [2s-[2alpha,5alpha,6beta(s*)]]-6-(aminophenylacetamido)-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate - Category
Authoritative Data Verified Data
B-lactam antibiotics, penicillins.
Last Update：2022-01-01 15:37:08
sodium [2s-[2alpha,5alpha,6beta(s*)]]-6-(aminophenylacetamido)-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate - Storage
Authoritative Data Verified Data
sealed and stored in a dry place.
Last Update：2022-01-01 15:37:08
sodium [2s-[2alpha,5alpha,6beta(s*)]]-6-(aminophenylacetamido)-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate - Ampicillin sodium for injection
Authoritative Data Verified Data
This product is a sterile powder of ampicillin sodium. The content of ampicillin (based on C16H19N304S) shall not be less than 85.0% calculated as anhydrous; The content of ampicillin (based on C16H19N304S) shall be 95.0% ~ 105.0% of the label amount calculated as average loading.
trait
This product is white or off-white powder or crystalline powder.
identification
take this product, according to ampicillin sodium under the identification test, the results of the apparent contrast.
examination
- the clarity and color of the solution take 5 bottles of this product, and add water separately according to the labeled amount to make the O in each lml. lg solution, the solution should be clear and colorless; If it is turbid, it should not be more concentrated than the 1# turbidity standard solution (General 0902 first method); If it is colored, no deeper than the yellow-green standard colorimetric solution No. 5 (general rule 0901 method 1).
- take an appropriate amount of water from this product and determine the water content according to the method of determination of water content (General rule 0832, first method 1). The water content shall not exceed 2.5%.
- insoluble particles this product is taken, and the solution containing 50mg per 1 ml of water is prepared by adding particles according to the labeled amount and checking according to law (General rule 0903), no more than 6000 particles of 10um or more and no more than 600 particles of 25um or more per 1.0g of sample shall be converted into a nominal amount of less than 1.0g; the labeled amount is more than 1.0g (including 6000g), and the particles containing 10um and lOum or more in each sample container shall not exceed 600 particles, and the particles containing 25um and 25um or more shall not exceed particles.
- alkalinity, related substances, bacterial endotoxin and sterility shall be checked according to the method of ampicillin sodium, and shall be in accordance with the regulations.
- others should comply with the relevant provisions under injection (General 0102).
Content determination
The contents under the item of loading amount difference were obtained by measuring according to the method of ampicillin sodium under the item.
category
Same as ampicillin sodium.
specification
calculated as C16H19N304S (1)0.5g (2)1.0g(3)2.0g
storage
sealed and stored in a dry place.
Last Update：2022-01-01 15:37:09
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Featured ProductsMultiple SpecificationsSpot supply
Product Name: Ampicillin sodium salt Visit Supplier Webpage Request for quotationCAS: 69-52-3
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Multiple SpecificationsSpot supply
Product Name: D-(-)-α-Aminobenzylpenicillin sodium salt Visit Supplier Webpage Request for quotationCAS: 69-52-3
Tel: 609-228-6898
Email: sales@medchemexpress.com
tech@medchemexpress.com
Mobile: 609-228-6898
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Product Name: Ampicillin sodium Visit Supplier Webpage Request for quotationCAS: 69-52-3
Tel: +86 0571-86722205
Email: sales@chinaskyrun.com
Mobile: +8618958170122
QQ: 2531159185
Wechat: chinaskyrun
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Product Name: Ampicillin sodium salt Visit Supplier Webpage Request for quotationCAS: 69-52-3
Tel: +86-400-900-4166
Email: product@acmec-e.com
Mobile: +86-18621343501
QQ: 2881950922
Wechat: 18621343501
WhatsApp: +86-18621343501
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Product Name: Ampicillin sodium salt Visit Supplier Webpage Request for quotationCAS: 69-52-3
Tel: +86-18821248368
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Mobile: +86-18821248368
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View History
Raw Materials for sodium [2s-[2alpha,5alpha,6beta(s*)]]-6-(aminophenylacetamido)-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate